Genetic and Therapeutic Aspects of Lipid and Purine Metabolism

This book, written as a Festschrift honoring Prof. Dr. N. Zollner, contains both survey articles and original material contributed by leading scientists in Europe and the United States. The genetic aspects discussed include DNA-polymorphisms in the diagnosis of familiar hypercholesterinemia, the LDL receptor, the characterisation of the scavenger receptor of the human liver, the expression of Apo AI, AII and CII genes in pro- and eukaryotic cells, and the disruption of purine enzymes. The articles on therapy deal with the newest information on prognosis and treatment with diet, increased physical activity and pharmaceuticals both for hyperlipidemias and gout. Special interest will be captured by the comparison of all known plasmapheresis procedures for the treatment of acute hypercholesterinemia.